NMR/MRI Articles

A Miniature Chip for Protein Detection Based on Magnetic Relaxation Switches

A Miniature Chip for Protein Detection Based on Magnetic Relaxation Switches

A Miniature Chip for Protein Detection Based on Magnetic Relaxation Switches Abstract  A miniature multi-sample chip for protein detection with a bench-top magnetic resonance imager was created on the basis of magnetic relaxation switches. The chip was assessed with two protein systems. Both qualitative and quantitative results for the target proteins were obtained by image analysis and relaxation time measurement, respectively. The detection of prostate specific antigen, the serum marker of human prostate cancer, showed a linear concentration range of 17.3–43.2 ngmL−1 and a detection limit of 13.7 ngmL−1. As proof of concept, the analysis of 18 samples with a volume of 6.37L each was completed in 26 min by this chip. This technique may become an easy and efficien……

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A Non-invasive NMR and MRI Method to Analyze the Rehydration of Dried Sea Cucumber

A Non-invasive NMR and MRI Method to Analyze the Rehydration of Dried Sea Cucumber

A Non-invasive NMR and MRI Method to Analyze the Rehydration of Dried Sea Cucumber Abstract  Sea cucumbers possess high-value and bioactive components that have been used for human food and pharmaceuticals in treating a wide number of ailments. Most of the sea cucumber products on the market are dehydrated due to the immediate autolysis that occurs upon removal of the sea cucumber from seawater. Rehydration of the dried products is necessary to obtain sea cucumbers with the highest water content. In this study, a rapid and non-invasive NMR and MRI method was introduced to analyze the rehydration process for dried sea cucumber. The spin–spin relaxation time (T2) weighted NMR signal, obtained by a CPMG pulse sequence and processed by the chemometric method, was used ……

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CBound Water Content and Pore Size Distribution in Swollen Cell Walls Determined by NMR Technology

CBound Water Content and Pore Size Distribution in Swollen Cell Walls Determined by NMR Technology

 CBound Water Content and Pore Size Distribution in Swollen Cell Walls Determined by NMR Technology Abstract  Nuclear magnetic resonance (NMR) relaxation time distributions can provide detailed information about the moisture in wood. In this paper, the bound water content and pore size distributions in swollen cell wall of two kinds of softwoods (Pinus sylvestris and Cunninghamia lanceolata) and three kinds of hardwoods (Populus sp., Fraxinus excelsior L., and Ochroma lagopus) were determined by NMR cryoporometry. The total bound water content of swollen cell wall almost exceeds 35%, based on dry mass, which is obviously higher than the fiber saturation point (FSP) (appr. 30%) measured by the extrapolation method. The bound water content of different species is con……

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Determining the Drying Degree and Quality of Chicken Jerky by LF-NMR

Determining the Drying Degree and Quality of Chicken Jerky by LF-NMR

 Determining the Drying Degree and Quality of Chicken Jerky by LF-NMR Abstract  The objective is to characterize the changes in water mobility in drying process of chicken breast using 1H low-field nuclear magnetic resonance (LF-NMR). Chicken breast was dried at different temperatures, i.e. 50 C, 55 C, 60 C, 65 C, 70 C and 75 C, respectively. Indicators related to water mobility were gained by LF-NMR and the shear force, the main relevant quality indicator, was also measured. The total water content measured by the conventional determination method-oven drying method were recorded and analyzed. The results showed that the total water content, the transverse relaxation time of immobilized water (T21) and the signal per mass of the immobilized water (A2) and th……

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Dextran-coated Superparamagnetic Amorphous Fe–Co Nanoalloy for Magnetic Resonance Imaging Applications

Dextran-coated Superparamagnetic Amorphous Fe–Co Nanoalloy for Magnetic Resonance Imaging Applications

 Dextran-coated Superparamagnetic Amorphous Fe–Co Nanoalloy for Magnetic Resonance Imaging Applications Abstract  For magnetic resonance imaging applications, a facile approach for water-soluble dextran coated amorphous Fe–Co nanoalloy was developed. The as-synthesized nanoalloy had a diameter of 9 nm with a narrow size distribution and showed superparamagnetic property with a saturated magnetization (Ms) of 25 emu/g. In vitro cytotoxicity test revealed that it was biocompatible at a concentration below 120 mg/mL. It can be uptaken by HeLa cells effectively and resulted in the obvious T2 effect after internalization. Biodistribution studies in conjunction with inductively coupled plasma-atomic emission spectroscopy (ICP-AES) confirmed that Fe–Co nanoalloy was prefe……

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