NIUMAG
Small Animal Body Composition Analysis
A Mouse Model of Intrahepatic Fat Content
Obesity has become a public health problem that endangers human health globally. Obese people are more likely to have high blood pressure, diabetes, fatty liver than normal people, and severe obesity can even lead to respiratory depression. Obesity is also an important factor in causing non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is a common liver disease with a prevalence of about 25%-40%.
Study on the mouse model of intrahepatic fat content
The traditional mouse model study of intrahepatic fat content can use chemical analysis, which is a standard measure of body composition. There is also bioelectrical impedance method (BIA), dual energy X-ray absorption spectrometry (DEXA), etc. These methods have shortcomings such as large error in measurement results, small scope of application, and easy influence. This application notes introduces the small animal body composition analysis technology based on low-field nuclear magnetic resonance technology, which is very suitable for the study of liver fat content in mouse models.
In addition to the mouse model study of intrahepatic fat content, small animal body composition analysis technology can also be used for the measurement of body composition of rats and mice in vivo.
Small Animal Body Composition Analysis
The small animal body composition analyzer can quickly, accurately and quantitatively measure the fat, lean meat and body fluid content of small animals when the small animal is awake and unrestrained, without anesthesia. Without any harm, it simplifies the experiment, saves the experimental cost, and carries out the follow-up study on a single mouse or small animal. By monitoring the physiological parameters of small animals for a long time, the effects of various drugs, exercise, external factors and nutrition on the physiological indicators of animals were investigated.
Small animal body composition analysis technology is mainly used for quantitative analysis of metabolism-related components such as fat, lean meat and body fluids, assisting in the screening of active ingredients in drugs, and the research on the etiology and pathogenic mechanism of metabolic diseases.
Small animal body composition analyzer performance characteristics:
- Quick test: the test is simple and fast, and the whole test process is within 1min;
- The sample does not need pretreatment: the sample does not need to be anesthetized or killed;
- Test results: The test results are fat content and muscle content, which are reliable and true, with high stability and good repeatability;
- Applicability: Small animals such as live rats, mice and rabbits can be measured;