Tecnología de detección rápida de nanosensor magnético de RMN pequeño de sobremesa

Tecnología de detección rápida de nanosensor magnético de RMN pequeño de sobremesa

With the development of nanotechnology, nanopartículas superparamagnéticas biofuncionalizadas (conectado con diferentes biomoléculas, como los ácidos nucleicos, moléculas pequeñas, péptidos, anticuerpos) han sido ampliamente desarrollados en términos de enriquecimiento biológico e identificación. The biofunctionalized magnetic beads are enriched on biomacromolecules, causing the change of transverse relaxation time (T2) in the system. This T2 change can be sensitively detected by low-field nuclear magnetic resonance. Combining the two can construct a new type of biomolecular recognition method with extremely low detection limit, strong specificity and rapidity. Actualmente, this technology has been applied to the detection of toxins, viruses, bacteria, heavy metals, and pathogenic bacteria.

Tecnología de detección rápida de nanosensor magnético de RMN pequeño de sobremesa

The basic principle of the detection mechanism of magnetic nanosensors is based on the ability of selective nanoparticles to switch between dispersed and aggregated states when interacting with the target. Variety. On the basis of T2 (ΔT2) changes, various molecular targets such as nucleic acids (DNA and mRNA), proteínas, and viruses can be detected.

Benchtop small NMR detection object

1. Viruses
2. Small molecules, péptidos
3. Nucleic acids (DNA and mRNA)
4. Bacteria, food-borne pathogens
5. Immunoglobulin
6. Toxins
7. Heavy Metals

Benchtop small NMR instrument parameters:

Probe coil diameter: 15milímetros

Sample dosage: 0.5-2ml

Advantages of Benchtop small NMR

1. Strong specificity (detection requires specific magnetic beads)
2. Rápido
3. Accurate
4. Very low detection limit
5. Alta sensibilidad
6. Mediciones realizadas por personal no capacitado.
7. Field testable