Live Mouse Body Composition Analysis by NMR

Live Mouse Body Composition Analysis by NMR

Live Mouse Body Composition Study

The study of intrahepatic fat content in live mouse models traditionally involves chemical analysis, which serves as a standard method for assessing live mouse body composition. However, alternative methods such as bioelectrical impedance (BIA) and dual-energy X-ray absorption spectrometry (DEXA) have limitations, including measurement errors, limited applicability, and susceptibility to external influences. This application note introduces a live mouse body composition analysis technology based on low-field NMR (Nuclear Magnetic Resonance), which is particularly suitable for studying liver fat content in rat models.

Aside from investigating intrahepatic fat content in mouse models, the live mouse body composition analysis technology can also be utilized for measuring the body composition of live mice and rats in vivo.

Live Mouse Body Composition Study by NMR

The live mouse body composition analyzer allows for quick, accurate, and quantitative measurements of fat, lean mass, and body fluid content in awake and unrestrained rats, eliminating the need for anesthesia. This non-invasive approach simplifies experiments, reduces experimental costs, and enables follow-up studies on individual rats or small animals. By monitoring the physiological parameters of rats over extended periods, researchers can investigate the effects of various drugs, exercise, external factors, and nutrition on the physiological indicators of the animals.

The primary application of live mouse body composition analysis technology lies in the quantitative analysis of metabolism-related components such as fat, lean mass, and body fluids. It assists in screening active ingredients in drugs and contributes to research on the etiology and pathogenic mechanisms of metabolic diseases.

Features of Live Mouse Body Composition Study by NMR

Key features of the live mouse body composition analyzer include:

Quick testing: The testing process is simple and fast, typically completed within 1 minute.
Sample does not require pretreatment: The samples do not need to be anesthetized or sacrificed.
Reliable test results: The analyzer provides accurate measurements of fat content and muscle content with high stability and good repeatability.
Applicability: It can be used to measure small animals such as live rats, mice, and rabbits.

This live mouse body composition analysis technology offers a valuable tool for researchers, providing efficient and reliable quantitative assessments of body composition in live animals. Its non-invasive nature and versatility make it a promising method for a wide range of studies, advancing our understanding of metabolic diseases and facilitating drug development research.